Ontology highlight
ABSTRACT:
SUBMITTER: Nicholson MJ
PROVIDER: S-EPMC3417822 | biostudies-literature | 2005 Oct
REPOSITORIES: biostudies-literature
Nicholson Melissa J MJ Hahn Michael M Wucherpfennig Kai W KW
Immunity 20051001 4
Structural studies on T cell receptors (TCRs) specific for foreign antigens demonstrated a remarkably similar topology characterized by a central, diagonal TCR binding mode that maximizes interactions with the MHC bound peptide. However, three recent structures involving autoimmune TCRs demonstrated unusual interactions with self-peptide/MHC complexes. Two TCRs from multiple sclerosis patients bind with unconventional topologies, and both TCRs are shifted toward the peptide N terminus and the MH ...[more]