Ontology highlight
ABSTRACT:
SUBMITTER: Blevins SJ
PROVIDER: S-EPMC5281623 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Blevins Sydney J SJ Baker Brian M BM
Frontiers in molecular biosciences 20170131
In cellular immunity, clonally distributed T cell receptors (TCRs) engage complexes of peptides bound to major histocompatibility complex proteins (pMHCs). In the interactions of TCRs with pMHCs, regions of restricted and variable diversity align in a structurally complex fashion. Many studies have used mutagenesis to attempt to understand the "roles" played by various interface components in determining TCR recognition properties such as specificity and cross-reactivity. However, these measurem ...[more]