Ontology highlight
ABSTRACT:
SUBMITTER: Su X
PROVIDER: S-EPMC3418222 | biostudies-literature | 2009 Jul
REPOSITORIES: biostudies-literature
Su Xiaohua X Paris Maryline M Gi Young Jin YJ Tsai Kenneth Y KY Cho Min Soon MS Lin Yu-Li YL Biernaskie Jeffrey A JA Sinha Satrajit S Prives Carol C Pevny Larysa H LH Miller Freda D FD Flores Elsa R ER
Cell stem cell 20090701 1
The cellular mechanisms that regulate the maintenance of adult tissue stem cells are still largely unknown. We show here that the p53 family member, TAp63, is essential for maintenance of epidermal and dermal precursors and that, in its absence, these precursors senesce and skin ages prematurely. Specifically, we have developed a TAp63 conditional knockout mouse and used it to ablate TAp63 in the germline (TAp63(-/-)) or in K14-expressing cells in the basal layer of the epidermis (TAp63(fl/fl);K ...[more]