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Copper-catalyzed oxytrifluoromethylation of unactivated alkenes.

ABSTRACT: A mild, versatile, and convenient method for the efficient oxytrifluoromethylation of unactivated alkenes based on a copper-catalyzed oxidative difunctionalization strategy has been developed. This methodology provides access to a variety of classes of synthetically useful CF(3)-containing building blocks from simple starting materials.

SUBMITTER: Zhu R

PROVIDER: S-EPMC3419474 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature

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Copper-catalyzed oxytrifluoromethylation of unactivated alkenes.

Zhu Rong R Buchwald Stephen L SL

Journal of the American Chemical Society 20120723 30

A mild, versatile, and convenient method for the efficient oxytrifluoromethylation of unactivated alkenes based on a copper-catalyzed oxidative difunctionalization strategy has been developed. This methodology provides access to a variety of classes of synthetically useful CF(3)-containing building blocks from simple starting materials. ...[more]

PMID: 22804336

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