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Copper-catalyzed diamination of unactivated alkenes with hydroxylamines.

ABSTRACT: A copper-catalyzed regio- and stereoselective diamination of unactivated alkenes has been developed with O-acylhydroxylamines as electrophilic nitrogen sources and oxidants. This method provides the first example of metal-catalyzed alkene diamination for directly installing an electron-rich amino group and extends the diamination scope for the synthesis of diverse 1,2-diamines. It offers a rapid and efficient approach to construct a wide range of 1,2-diamines that are an important structural motif in organic synthesis, medicines, catalysts and ligands.

SUBMITTER: Shen K

PROVIDER: S-EPMC5707484 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature

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Copper-catalyzed diamination of unactivated alkenes with hydroxylamines.

Shen Kun K Wang Qiu Q

Chemical science 20150518 7

A copper-catalyzed regio- and stereoselective diamination of unactivated alkenes has been developed with <i>O</i>-acylhydroxylamines as electrophilic nitrogen sources and oxidants. This method provides the first example of metal-catalyzed alkene diamination for directly installing an electron-rich amino group and extends the diamination scope for the synthesis of diverse 1,2-diamines. It offers a rapid and efficient approach to construct a wide range of 1,2-diamines that are an important structu ...[more]

PMID: 29218196

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