Ontology highlight
ABSTRACT:
SUBMITTER: Favreau P
PROVIDER: S-EPMC3419909 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Favreau Philippe P Benoit Evelyne E Hocking Henry G HG Carlier Ludovic L D' hoedt Dieter D Leipold Enrico E Markgraf René R Schlumberger Sébastien S Córdova Marco A MA Gaertner Hubert H Paolini-Bertrand Marianne M Hartley Oliver O Tytgat Jan J Heinemann Stefan H SH Bertrand Daniel D Boelens Rolf R Stöcklin Reto R Molgó Jordi J
British journal of pharmacology 20120701 5
<h4>Background and purpose</h4>The µ-conopeptide family is defined by its ability to block voltage-gated sodium channels (VGSCs), a property that can be used for the development of myorelaxants and analgesics. We characterized the pharmacology of a new µ-conopeptide (µ-CnIIIC) on a range of preparations and molecular targets to assess its potential as a myorelaxant.<h4>Experimental approach</h4>µ-CnIIIC was sequenced, synthesized and characterized by its direct block of elicited twitch tension i ...[more]