Mild exercise increases dihydrotestosterone in hippocampus providing evidence for androgenic mediation of neurogenesis.
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ABSTRACT:
SUBMITTER: Okamoto M
PROVIDER: S-EPMC3420174 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
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Mild exercise increases dihydrotestosterone in hippocampus providing evidence for androgenic mediation of neurogenesis.
Okamoto Masahiro M Hojo Yasushi Y Inoue Koshiro K Matsui Takashi T Kawato Suguru S McEwen Bruce S BS Soya Hideaki H
Proceedings of the National Academy of Sciences of the United States of America 20120717 32
Mild exercise activates hippocampal neurons through the glutamatergic pathway and also promotes adult hippocampal neurogenesis (AHN). We hypothesized that such exercise could enhance local androgen synthesis and cause AHN because hippocampal steroid synthesis is facilitated by activated neurons via N-methyl-D-aspartate receptors. Here we addressed this question using a mild-intense treadmill running model that has been shown to be a potent AHN stimulator. A mass-spectrometric analysis demonstrat ...[more]
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