Ontology highlight
ABSTRACT:
SUBMITTER: Mathews KJ
PROVIDER: S-EPMC5595679 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Mathews Kathryn J KJ Allen Katherine M KM Boerrigter Danny D Ball Helen H Shannon Weickert Cynthia C Double Kay L KL
Aging cell 20170801 5
Reduced neurogenesis in the aging mammalian hippocampus has been linked to cognitive deficits and increased risk of dementia. We utilized postmortem human hippocampal tissue from 26 subjects aged 18-88 years to investigate changes in expression of six genes representing different stages of neurogenesis across the healthy adult lifespan. Progressive and significant decreases in mRNA levels of the proliferation marker Ki67 (MKI67) and the immature neuronal marker doublecortin (DCX) were found in t ...[more]