Ontology highlight
ABSTRACT:
SUBMITTER: Lee JH
PROVIDER: S-EPMC3420359 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Lee Jin Hee JH Lee Yoonji Y Ryu HyungChul H Kang Dong Wook DW Lee Jeewoo J Lazar Jozsef J Pearce Larry V LV Pavlyukovets Vladimir A VA Blumberg Peter M PM Choi Sun S
Journal of computer-aided molecular design 20110330 4
The transient receptor potential vanilloid subtype 1 (TRPV1) is a non-selective cation channel composed of four monomers with six transmembrane helices (TM1-TM6). TRPV1 is found in the central and peripheral nervous system, and it is an important therapeutic target for pain relief. We describe here the construction of a tetrameric homology model of rat TRPV1 (rTRPV1). We experimentally evaluated by mutational analysis the contribution of residues of rTRPV1 contributing to ligand binding by the p ...[more]