Ontology highlight
ABSTRACT:
SUBMITTER: Ohbuchi K
PROVIDER: S-EPMC5015962 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Ohbuchi Katsuya K Mori Yoshikazu Y Ogawa Kazuo K Warabi Eiji E Yamamoto Masahiro M Hirokawa Takatsugu T
PloS one 20160908 9
Transient receptor potential vanilloid type 1 (TRPV1) is a non-selective cation channel and a multimodal sensor protein. Since the precise structure of TRPV1 was obtained by electron cryo-microscopy, the binding mode of representative agonists such as capsaicin and resiniferatoxin (RTX) has been extensively characterized; however, detailed information on the binding mode of other vanilloids remains lacking. In this study, mutational analysis of human TRPV1 was performed, and four agonists (capsa ...[more]