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Pathological crystallization of human immunoglobulins.

ABSTRACT: Condensation of Igs has been observed in pharmaceutical formulations and in vivo in cases of cryoglobulinemia. We report a study of monoclonal IgG cryoglobulins overexpressed by two patients with multiple myeloma. These cryoglobulins form crystals, and we measured their solubility lines. Depending on the supersaturation, we observed a variety of condensate morphologies consistent with those reported in clinical investigations. Remarkably, the crystallization can occur at quite low concentrations. This suggests that, even within the regular immune response to infections, cryoprecipitation of Ig can be possible.

SUBMITTER: Wang Y

PROVIDER: S-EPMC3421172 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature

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Pathological crystallization of human immunoglobulins.

Wang Ying Y Lomakin Aleksey A Hideshima Teru T Laubach Jacob P JP Ogun Olutayo O Richardson Paul G PG Munshi Nikhil C NC Anderson Kenneth C KC Benedek George B GB

Proceedings of the National Academy of Sciences of the United States of America 20120730 33

Condensation of Igs has been observed in pharmaceutical formulations and in vivo in cases of cryoglobulinemia. We report a study of monoclonal IgG cryoglobulins overexpressed by two patients with multiple myeloma. These cryoglobulins form crystals, and we measured their solubility lines. Depending on the supersaturation, we observed a variety of condensate morphologies consistent with those reported in clinical investigations. Remarkably, the crystallization can occur at quite low concentrations ...[more]

PMID: 22847421

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