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Fluoxetine is a potent inhibitor of coxsackievirus replication.

ABSTRACT: No antiviral drugs currently exist for the treatment of enterovirus infections, which are often severe and potentially life threatening. Molecular screening of small molecule libraries identified fluoxetine, a selective serotonin reuptake inhibitor, as a potent inhibitor of coxsackievirus replication. Fluoxetine did not interfere with either viral entry or translation of the viral genome. Instead, fluoxetine and its metabolite norfluoxetine markedly reduced the synthesis of viral RNA and protein. In view of its favorable pharmacokinetics and safety profile, fluoxetine warrants additional study as a potential antiviral agent for enterovirus infections.

SUBMITTER: Zuo J

PROVIDER: S-EPMC3421851 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature

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Fluoxetine is a potent inhibitor of coxsackievirus replication.

Zuo Jun J Quinn Kevin K KK Kye Steve S Cooper Paige P Damoiseaux Robert R Krogstad Paul P

Antimicrobial agents and chemotherapy 20120702 9

No antiviral drugs currently exist for the treatment of enterovirus infections, which are often severe and potentially life threatening. Molecular screening of small molecule libraries identified fluoxetine, a selective serotonin reuptake inhibitor, as a potent inhibitor of coxsackievirus replication. Fluoxetine did not interfere with either viral entry or translation of the viral genome. Instead, fluoxetine and its metabolite norfluoxetine markedly reduced the synthesis of viral RNA and protein ...[more]

PMID: 22751539

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