Ontology highlight
ABSTRACT:
SUBMITTER: Kircher MF
PROVIDER: S-EPMC3422133 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
Kircher Moritz F MF de la Zerda Adam A Jokerst Jesse V JV Zavaleta Cristina L CL Kempen Paul J PJ Mittra Erik E Pitter Ken K Huang Ruimin R Campos Carl C Habte Frezghi F Sinclair Robert R Brennan Cameron W CW Mellinghoff Ingo K IK Holland Eric C EC Gambhir Sanjiv S SS
Nature medicine 20120415 5
The difficulty in delineating brain tumor margins is a major obstacle in the path toward better outcomes for patients with brain tumors. Current imaging methods are often limited by inadequate sensitivity, specificity and spatial resolution. Here we show that a unique triple-modality magnetic resonance imaging-photoacoustic imaging-Raman imaging nanoparticle (termed here MPR nanoparticle) can accurately help delineate the margins of brain tumors in living mice both preoperatively and intraoperat ...[more]