Dataset Information

A quantitative model of human jejunal smooth muscle cell electrophysiology.

ABSTRACT: Recently, a number of ion channel mutations have been identified in the smooth muscle cells of the human jejunum. Although these are potentially significant in understanding diseases that are currently of unknown etiology, no suitable computational cell model exists to evaluate the effects of such mutations. Here, therefore, a biophysically based single cell model of human jejunal smooth muscle electrophysiology is presented. The resulting cellular description is able to reproduce experimentally recorded slow wave activity and produces realistic responses to a number of perturbations, providing a solid platform on which the causes of intestinal myopathies can be investigated.

SUBMITTER: Poh YC

PROVIDER: S-EPMC3422293 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature

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A quantitative model of human jejunal smooth muscle cell electrophysiology.

Poh Yong Cheng YC Corrias Alberto A Cheng Nicholas N Buist Martin Lindsay ML

PloS one 20120817 8

Recently, a number of ion channel mutations have been identified in the smooth muscle cells of the human jejunum. Although these are potentially significant in understanding diseases that are currently of unknown etiology, no suitable computational cell model exists to evaluate the effects of such mutations. Here, therefore, a biophysically based single cell model of human jejunal smooth muscle electrophysiology is presented. The resulting cellular description is able to reproduce experimentally ...[more]

PMID: 22912702

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Dataset Information

A quantitative model of human jejunal smooth muscle cell electrophysiology.

Publications

A quantitative model of human jejunal smooth muscle cell electrophysiology.

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