Interactions among capsid proteins orchestrate rotavirus particle functions.
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ABSTRACT:
SUBMITTER: Trask SD
PROVIDER: S-EPMC3422376 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
Publications
Interactions among capsid proteins orchestrate rotavirus particle functions.
Trask Shane D SD Ogden Kristen M KM Patton John T JT
Current opinion in virology 20120516 4
Rotaviruses are members of the Reoviridae family of non-enveloped viruses and important etiologic agents of acute gastroenteritis in infants and young children. In recent years, high-resolution structures of triple-layered rotavirus virions and the constituent proteins have provided valuable insights into functions. Of note, structural studies have revealed the position of the viral RNA-dependent RNA polymerase, VP1, within the inner capsid, which in turn provides clues about the location of the ...[more]
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