Regulation of rotavirus polymerase activity by inner capsid proteins.
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ABSTRACT:
SUBMITTER: Gridley CL
PROVIDER: S-EPMC4268341 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Publications
Regulation of rotavirus polymerase activity by inner capsid proteins.
Gridley Chelsea L CL Patton John T JT
Current opinion in virology 20140920
Rotavirus, a cause of pediatric gastroenteritis, has a genome consisting of 11 segments of double-stranded (ds)RNA surrounded by a triple-layered protein capsid. The rotavirus RNA-dependent RNA polymerase, VP1, synthesizes both dsRNA and plus-strand RNA (+RNA) within subviral particles. Structural analyses of the rotavirus capsid and polymerase, combined with functional studies of purified capsid proteins, indicate that the inner capsid protein controls the initiation of RNA synthesis by VP1. Wh ...[more]
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