Small GTPase R-Ras regulates integrity and functionality of tumor blood vessels.
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ABSTRACT:
SUBMITTER: Sawada J
PROVIDER: S-EPMC3422514 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
Publications
Small GTPase R-Ras regulates integrity and functionality of tumor blood vessels.
Sawada Junko J Urakami Takeo T Li Fangfei F Urakami Akane A Zhu Weiquan W Fukuda Minoru M Li Dean Y DY Ruoslahti Erkki E Komatsu Masanobu M
Cancer cell 20120801 2
We show that R-Ras, a small GTPase of the Ras family, is essential for the establishment of mature, functional blood vessels in tumors. The genetic disruption of R-Ras severely impaired the maturation processes of tumor vessels in mice. Conversely, the gain of function of R-Ras improved vessel structure and blood perfusion and blocked plasma leakage by enhanced endothelial barrier function and pericyte association with nascent blood vessels. Thus, R-Ras promotes normalization of the tumor vascul ...[more]
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