Ontology highlight
ABSTRACT:
SUBMITTER: Grimsley-Myers CM
PROVIDER: S-EPMC2847287 | biostudies-other | 2009 Dec
REPOSITORIES: biostudies-other
Grimsley-Myers Cynthia M CM Sipe Conor W CW Géléoc Gwenaëlle S G GS Lu Xiaowei X
The Journal of neuroscience : the official journal of the Society for Neuroscience 20091201 50
Morphogenesis of sensory hair cells, in particular their mechanotransduction organelle, the stereociliary bundle, requires highly organized remodeling of the actin cytoskeleton. The roles of Rho family small GTPases during this process remain unknown. Here we show that deletion of Rac1 in the otic epithelium resulted in severe defects in cochlear epithelial morphogenesis. The mutant cochlea was severely shortened with a reduced number of auditory hair cells and cellular organization of the audit ...[more]