Ontology highlight
ABSTRACT:
SUBMITTER: Hathaway NA
PROVIDER: S-EPMC3422694 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
Hathaway Nathaniel A NA Bell Oliver O Hodges Courtney C Miller Erik L EL Neel Dana S DS Crabtree Gerald R GR
Cell 20120614 7
Posttranslational histone modifications are important for gene regulation, yet the mode of propagation and the contribution to heritable gene expression states remains controversial. To address these questions, we developed a chromatin in vivo assay (CiA) system employing chemically induced proximity to initiate and terminate chromatin modifications in living cells. We selectively recruited HP1α to induce H3K9me3-dependent gene silencing and describe the kinetics and extent of chromatin modifica ...[more]