Ontology highlight
ABSTRACT:
SUBMITTER: Gohara DW
PROVIDER: S-EPMC3191250 | biostudies-literature | 2011 Nov
REPOSITORIES: biostudies-literature
Gohara David W DW Di Cera Enrico E
Trends in biotechnology 20110702 11
Trypsin-like proteases (TLPs) are a large family of enzymes responsible for digestion, blood coagulation, fibrinolysis, development, fertilization, apoptosis and immunity. A current paradigm posits that the irreversible transition from an inactive zymogen to the active protease form enables productive interaction with substrate and catalysis. Analysis of the entire structural database reveals two distinct conformations of the active site: one fully accessible to substrate (E) and the other occlu ...[more]