Ontology highlight
ABSTRACT:
SUBMITTER: Gonzalez SF
PROVIDER: S-EPMC3424101 | biostudies-literature | 2010 May
REPOSITORIES: biostudies-literature
Gonzalez Santiago F SF Lukacs-Kornek Veronika V Kuligowski Michael P MP Pitcher Lisa A LA Degn Søren E SE Kim Young-A YA Cloninger Mary J MJ Martinez-Pomares Luisa L Gordon Siamon S Turley Shannon J SJ Carroll Michael C MC
Nature immunology 20100321 5
A major pathway for B cell acquisition of lymph-borne particulate antigens relies on antigen capture by subcapsular sinus macrophages of the lymph node. Here we tested whether this mechanism is also important for humoral immunity to inactivated influenza virus. By multiple approaches, including multiphoton intravital imaging, we found that antigen capture by sinus-lining macrophages was important for limiting the systemic spread of virus but not for the generation of influenza-specific humoral i ...[more]