Ontology highlight
ABSTRACT:
SUBMITTER: Yamaguchi Y
PROVIDER: S-EPMC3424169 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Yamaguchi Yoshitaka Y Miyata Hironori H Uchiyama Keiji K Ootsuyama Akira A Inubushi Sachiko S Mori Tsuyoshi T Muramatsu Naomi N Katamine Shigeru S Sakaguchi Suehiro S
PloS one 20120821 8
Accumulating lines of evidence indicate that the N-terminal domain of prion protein (PrP) is involved in prion susceptibility in mice. In this study, to investigate the role of the octapeptide repeat (OR) region alone in the N-terminal domain for the susceptibility and pathogenesis of prion disease, we intracerebrally inoculated RML scrapie prions into tg(PrPΔOR)/Prnp(0/0) mice, which express mouse PrP missing only the OR region on the PrP-null background. Incubation times of these mice were not ...[more]