Healthy goats naturally devoid of prion protein.
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ABSTRACT:
SUBMITTER: Benestad SL
PROVIDER: S-EPMC3542104 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
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Healthy goats naturally devoid of prion protein.
Benestad Sylvie L SL Austbø Lars L Tranulis Michael A MA Espenes Arild A Olsaker Ingrid I
Veterinary research 20121218
Prion diseases such as scrapie in small ruminants, bovine spongiform encephalopathy (BSE) in cattle and Creutzfeldt-Jakob disease (CJD) in man, are fatal neurodegenerative disorders. These diseases result from the accumulation of misfolded conformers of the host-encoded prion protein (PrP) in the central nervous system. To date naturally-occurring PrP free animals have not been reported. Here we describe healthy non-transgenic animals, Norwegian Dairy Goats, lacking prion protein due to a nonsen ...[more]
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