Ontology highlight
ABSTRACT:
SUBMITTER: Tzur YB
PROVIDER: S-EPMC3424243 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Tzur Yonatan B YB Egydio de Carvalho Carlos C Nadarajan Saravanapriah S Van Bostelen Ivo I Gu Yanjie Y Chu Diana S DS Cheeseman Iain M IM Colaiácovo Monica P MP
PLoS biology 20120821 8
Successful execution of the meiotic program depends on the timely establishment and removal of sister chromatid cohesion. LAB-1 has been proposed to act in the latter by preventing the premature removal of the meiosis-specific cohesin REC-8 at metaphase I in C. elegans, yet the mechanism and scope of LAB-1 function remained unknown. Here we identify an unexpected earlier role for LAB-1 in promoting the establishment of sister chromatid cohesion in prophase I. LAB-1 and REC-8 are both required fo ...[more]