Ontology highlight
ABSTRACT:
SUBMITTER: Shang Y
PROVIDER: S-EPMC3424274 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Shang Yuhua Y Haynes Paula P Pírez Nicolás N Harrington Kyle I KI Guo Fang F Pollack Jordan J Hong Pengyu P Griffith Leslie C LC Rosbash Michael M
Nature neuroscience 20110619 7
How animals maintain proper amounts of sleep yet remain flexible to changes in environmental conditions remains unknown. We found that environmental light suppressed the wake-promoting effects of dopamine in fly brains. The ten large lateral-ventral neurons (l-LNvs), a subset of clock neurons, are wake-promoting and respond to dopamine, octopamine and light. Behavioral and imaging analyses suggested that dopamine is a stronger arousal signal than octopamine. Notably, light exposure not only supp ...[more]