Ontology highlight
ABSTRACT:
SUBMITTER: Mitch Taylor I
PROVIDER: S-EPMC3424350 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Mitch Taylor I I Jaquins-Gerstl Andrea A Sesack Susan R SR Michael Adrian C AC
Journal of neurochemistry 20120528 2
The rat dorsal striatum exhibits domain-dependent kinetics of dopamine release and clearance. The present report describes the domain-dependent actions of nomifensine (20 mg/kg i.p.), a competitive dopamine uptake inhibitor, on evoked dopamine responses recorded by voltammetry during electrical stimulation of the medial forebrain bundle. In slow domains, nomifensine increases the initial rate of evoked overflow, increases response overshoot, does not affect the slope of the linear segment of the ...[more]