Ontology highlight
ABSTRACT:
SUBMITTER: Zorman S
PROVIDER: S-EPMC3424547 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
Zorman Sylvain S Seitz H H Sclavi B B Strick T R TR
Nucleic acids research 20120511 15
In most bacteria, the timing and synchrony of initiation of chromosomal replication are determined by the binding of the AAA(+) protein DnaA to a set of high- and low-affinity sites found within the origin of chromosomal replication (oriC). Despite the large amount of information on the role and regulation of DnaA, the actual structure of the DnaA-oriC complex and the mechanism by which it primes the origin for the initiation of replication remain unclear. In this study, we have performed magnet ...[more]