Ontology highlight
ABSTRACT:
SUBMITTER: Kadauke S
PROVIDER: S-EPMC3425057 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
Kadauke Stephan S Udugama Maheshi I MI Pawlicki Jan M JM Achtman Jordan C JC Jain Deepti P DP Cheng Yong Y Hardison Ross C RC Blobel Gerd A GA
Cell 20120801 4
Tissue-specific transcription patterns are preserved throughout cell divisions to maintain lineage fidelity. We investigated whether transcription factor GATA1 plays a role in transmitting hematopoietic gene expression programs through mitosis when transcription is transiently silenced. Live-cell imaging revealed that a fraction of GATA1 is retained focally within mitotic chromatin. ChIP-seq of highly purified mitotic cells uncovered that key hematopoietic regulatory genes are occupied by GATA1 ...[more]