Ontology highlight
ABSTRACT:
SUBMITTER: Morales-Corraliza J
PROVIDER: S-EPMC3426627 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
Morales-Corraliza Jose J Schmidt Stephen D SD Mazzella Matthew J MJ Berger Jason D JD Wilson Donald A DA Wesson Daniel W DW Jucker Mathias M Levy Efrat E Nixon Ralph A RA Mathews Paul M PM
Neurobiology of aging 20120518 1
Although anti-human β-amyloid (Aβ) immunotherapy clears brain β-amyloid plaques in Alzheimer's disease (AD), targeting additional brain plaque constituents to promote clearance has not been attempted. Endogenous murine Aβ is a minor Aβ plaque component in amyloid precursor protein (APP) transgenic AD models, which we show is ∼3%-8% of the total accumulated Aβ in various human APP transgenic mice. Murine Aβ codeposits and colocalizes with human Aβ in amyloid plaques, and the two Aβ species coimmu ...[more]