Ontology highlight
ABSTRACT:
SUBMITTER: Qing H
PROVIDER: S-EPMC2585842 | biostudies-other | 2008 Nov
REPOSITORIES: biostudies-other
Qing Hong H He Guiqiong G Ly Philip T T PT Fox Christopher J CJ Staufenbiel Matthias M Cai Fang F Zhang Zhuohua Z Wei Shengcai S Sun Xiulian X Chen Chia-Hsiung CH Zhou Weihui W Wang Ke K Song Weihong W
The Journal of experimental medicine 20081027 12
Neuritic plaques in the brains are one of the pathological hallmarks of Alzheimer's disease (AD). Amyloid beta-protein (Abeta), the central component of neuritic plaques, is derived from beta-amyloid precursor protein (APP) after beta- and gamma-secretase cleavage. The molecular mechanism underlying the pathogenesis of AD is not yet well defined, and there has been no effective treatment for AD. Valproic acid (VPA) is one of the most widely used anticonvulsant and mood-stabilizing agents for tre ...[more]