Ontology highlight
ABSTRACT:
SUBMITTER: Schenk D
PROVIDER: S-EPMC3426815 | biostudies-literature | 2012 Sep
REPOSITORIES: biostudies-literature
Schenk Dale D Basi Guriqbal S GS Pangalos Menelas N MN
Cold Spring Harbor perspectives in medicine 20120901 9
With the advent of the key discovery in the mid-1980s that the amyloid β-protein (Aβ) is the core constituent of the amyloid plaque pathology found in Alzheimer disease (AD), an intensive effort has been underway to attempt to mitigate its role in the hope of treating the disease. This effort fully matured when it was clarified that the Aβ is a normal product of cleavage of the amyloid precursor protein, and well-defined proteases for this process were identified. Further therapeutic options hav ...[more]