Ontology highlight
ABSTRACT:
SUBMITTER: Shaw PX
PROVIDER: S-EPMC3427125 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
Shaw Peter X PX Zhang Li L Zhang Ming M Du Hongjun H Zhao Ling L Lee Clara C Grob Seanna S Lim Siok Lam SL Hughes Guy G Lee Janet J Bedell Matthew M Nelson Mark H MH Lu Fang F Krupa Martin M Luo Jing J Ouyang Hong H Tu Zhidan Z Su Zhiguang Z Zhu Jin J Wei Xinran X Feng Zishan Z Duan Yaou Y Yang Zhenglin Z Ferreyra Henry H Bartsch Dirk-Uwe DU Kozak Igor I Zhang Liangfang L Lin Feng F Sun Hui H Feng Hong H Zhang Kang K
Proceedings of the National Academy of Sciences of the United States of America 20120808 34
The rs1061170T/C variant encoding the Y402H change in complement factor H (CFH) has been identified by genome-wide association studies as being significantly associated with age-related macular degeneration (AMD). However, the precise mechanism by which this CFH variant impacts the risk of AMD remains largely unknown. Oxidative stress plays an important role in many aging diseases, including cardiovascular disease and AMD. A large amount of oxidized phospholipids (oxPLs) are generated in the eye ...[more]