Ontology highlight
ABSTRACT:
SUBMITTER: Jaciuk M
PROVIDER: S-EPMC3428727 | biostudies-literature | 2011 Feb
REPOSITORIES: biostudies-literature
Jaciuk Marcin M Nowak Elżbieta E Skowronek Krzysztof K Tańska Anna A Nowotny Marcin M
Nature structural & molecular biology 20110116 2
One of the primary pathways for removal of DNA damage is nucleotide excision repair (NER). In bacteria, the UvrA protein is the component of NER that locates the lesion. A notable feature of NER is its ability to act on many DNA modifications that vary in chemical structure. So far, the mechanism underlying this broad specificity has been unclear. Here, we report the first crystal structure of a UvrA protein in complex with a chemically modified oligonucleotide. The structure shows that the UvrA ...[more]