Ontology highlight
ABSTRACT:
SUBMITTER: Wang ET
PROVIDER: S-EPMC3428802 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
Cell 20120801 4
The muscleblind-like (Mbnl) family of RNA-binding proteins plays important roles in muscle and eye development and in myotonic dystrophy (DM), in which expanded CUG or CCUG repeats functionally deplete Mbnl proteins. We identified transcriptome-wide functional and biophysical targets of Mbnl proteins in brain, heart, muscle, and myoblasts by using RNA-seq and CLIP-seq approaches. This analysis identified several hundred splicing events whose regulation depended on Mbnl function in a pattern indi ...[more]