Ontology highlight
ABSTRACT:
SUBMITTER: Tsuruda PR
PROVIDER: S-EPMC3014052 | biostudies-literature | 2006 Jul
REPOSITORIES: biostudies-literature
Tsuruda Pamela R PR Julius David D Minor Daniel L DL
Neuron 20060701 2
Transient receptor potential (TRP) channels mediate numerous sensory transduction processes and are thought to function as tetramers. TRP channel physiology is well studied; however, comparatively little is understood regarding TRP channel assembly. Here, we identify an autonomously folded assembly domain from the cold- and menthol-gated channel TRPM8. We show that the TRPM8 cytoplasmic C-terminal domain contains a coiled coil that is necessary for channel assembly and sufficient for tetramer fo ...[more]