The landscape of cancer genes and mutational processes in breast cancer.
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ABSTRACT:
SUBMITTER: Stephens PJ
PROVIDER: S-EPMC3428862 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Publications
The landscape of cancer genes and mutational processes in breast cancer.
Stephens Philip J PJ Tarpey Patrick S PS Davies Helen H Van Loo Peter P Greenman Chris C Wedge David C DC Nik-Zainal Serena S Martin Sancha S Varela Ignacio I Bignell Graham R GR Yates Lucy R LR Papaemmanuil Elli E Beare David D Butler Adam A Cheverton Angela A Gamble John J Hinton Jonathan J Jia Mingming M Jayakumar Alagu A Jones David D Latimer Calli C Lau King Wai KW McLaren Stuart S McBride David J DJ Menzies Andrew A Mudie Laura L Raine Keiran K Rad Roland R Chapman Michael Spencer MS Teague Jon J Easton Douglas D Langerød Anita A Lee Ming Ta Michael MT Shen Chen-Yang CY Tee Benita Tan Kiat BT Huimin Bernice Wong BW Broeks Annegien A Vargas Ana Cristina AC Turashvili Gulisa G Martens John J Fatima Aquila A Miron Penelope P Chin Suet-Feung SF Thomas Gilles G Boyault Sandrine S Mariani Odette O Lakhani Sunil R SR van de Vijver Marc M van 't Veer Laura L Foekens John J Desmedt Christine C Sotiriou Christos C Tutt Andrew A Caldas Carlos C Reis-Filho Jorge S JS Aparicio Samuel A J R SA Salomon Anne Vincent AV Børresen-Dale Anne-Lise AL Richardson Andrea L AL Campbell Peter J PJ Futreal P Andrew PA Stratton Michael R MR
Nature 20120516 7403
All cancers carry somatic mutations in their genomes. A subset, known as driver mutations, confer clonal selective advantage on cancer cells and are causally implicated in oncogenesis, and the remainder are passenger mutations. The driver mutations and mutational processes operative in breast cancer have not yet been comprehensively explored. Here we examine the genomes of 100 tumours for somatic copy number changes and mutations in the coding exons of protein-coding genes. The number of somatic ...[more]
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