Ontology highlight
ABSTRACT:
SUBMITTER: Morganella S
PROVIDER: S-EPMC5001788 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Morganella Sandro S Alexandrov Ludmil B LB Glodzik Dominik D Zou Xueqing X Davies Helen H Staaf Johan J Sieuwerts Anieta M AM Brinkman Arie B AB Martin Sancha S Ramakrishna Manasa M Butler Adam A Kim Hyung-Yong HY Borg Åke Å Sotiriou Christos C Futreal P Andrew PA Campbell Peter J PJ Span Paul N PN Van Laere Steven S Lakhani Sunil R SR Eyfjord Jorunn E JE Thompson Alastair M AM Stunnenberg Hendrik G HG van de Vijver Marc J MJ Martens John W M JW Børresen-Dale Anne-Lise AL Richardson Andrea L AL Kong Gu G Thomas Gilles G Sale Julian J Rada Cristina C Stratton Michael R MR Birney Ewan E Nik-Zainal Serena S
Nature communications 20160502
Somatic mutations in human cancers show unevenness in genomic distribution that correlate with aspects of genome structure and function. These mutations are, however, generated by multiple mutational processes operating through the cellular lineage between the fertilized egg and the cancer cell, each composed of specific DNA damage and repair components and leaving its own characteristic mutational signature on the genome. Using somatic mutation catalogues from 560 breast cancer whole-genome seq ...[more]