Ontology highlight
ABSTRACT:
SUBMITTER: Ingason A
PROVIDER: S-EPMC3428917 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Ingason Andrés A Kirov George G Giegling Ina I Hansen Thomas T Isles Anthony R AR Jakobsen Klaus D KD Kristinsson Kari T KT le Roux Louise L Gustafsson Omar O Craddock Nick N Möller Hans-Jürgen HJ McQuillin Andrew A Muglia Pierandrea P Cichon Sven S Rietschel Marcella M Ophoff Roel A RA Djurovic Srdjan S Andreassen Ole A OA Pietiläinen Olli P H OP Peltonen Leena L Dempster Emma E Collier David A DA St Clair David D Rasmussen Henrik B HB Glenthøj Birte Y BY Kiemeney Lambertus A LA Franke Barbara B Tosato Sarah S Bonetto Chiara C Saemundsen Evald E Hreidarsson Stefán J SJ Nöthen Markus M MM Gurling Hugh H O'Donovan Michael C MC Owen Michael J MJ Sigurdsson Engilbert E Petursson Hannes H Stefansson Hreinn H Rujescu Dan D Stefansson Kari K Werge Thomas T
The American journal of psychiatry 20110215 4
<h4>Objective</h4>Rare copy number variants have been implicated in different neurodevelopmental disorders, with the same copy number variants often increasing risk of more than one of these phenotypes. In a discovery sample of 22 schizophrenia patients with an early onset of illness (10-15 years of age), the authors observed in one patient a maternally derived 15q11-q13 duplication overlapping the Prader-Willi/Angelman syndrome critical region. This prompted investigation of the role of 15q11-q ...[more]