Ontology highlight
ABSTRACT:
SUBMITTER: Venereau E
PROVIDER: S-EPMC3428943 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
Venereau Emilie E Casalgrandi Maura M Schiraldi Milena M Antoine Daniel J DJ Cattaneo Angela A De Marchis Francesco F Liu Jaron J Antonelli Antonella A Preti Alessandro A Raeli Lorenzo L Shams Sara Samadi SS Yang Huan H Varani Luca L Andersson Ulf U Tracey Kevin J KJ Bachi Angela A Uguccioni Mariagrazia M Bianchi Marco E ME
The Journal of experimental medicine 20120806 9
Tissue damage causes inflammation, by recruiting leukocytes and activating them to release proinflammatory mediators. We show that high-mobility group box 1 protein (HMGB1) orchestrates both processes by switching among mutually exclusive redox states. Reduced cysteines make HMGB1 a chemoattractant, whereas a disulfide bond makes it a proinflammatory cytokine and further cysteine oxidation to sulfonates by reactive oxygen species abrogates both activities. We show that leukocyte recruitment and ...[more]