Ontology highlight
ABSTRACT:
SUBMITTER: Wang Z
PROVIDER: S-EPMC3430276 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Wang Zhanli Z Sun Lidan L Yu Hui H Zhang Yanhui Y Gong Wuzhuang W Jin Hongwei H Zhang Liangren L Liang Huaping H
International journal of molecular sciences 20120718 7
Accurate assessment of the potential binding mode of drugs is crucial to computer-aided drug design paradigms. It has been reported that evodiamine acts as an agonist of the vanilloid receptor Transient receptor potential vanilloid-1 (TRPV1). However, the precise interaction between evodiamine and TRPV1 was still not fully understood. In this perspective, the homology models of TRPV1 were generated using the crystal structure of the voltage-dependent shaker family K(+) channel as a template. We ...[more]