Ontology highlight
ABSTRACT:
SUBMITTER: Djagaeva I
PROVIDER: S-EPMC3430534 | biostudies-literature | 2012 Sep
REPOSITORIES: biostudies-literature
Djagaeva Inna I Rose Debra J DJ Lim Angeline A Venter Chris E CE Brendza Katherine M KM Moua Pangkong P Saxton William M WM
Genetics 20120619 1
Kinesin-1 is a motor protein that moves stepwise along microtubules by employing dimerized kinesin heavy chain (Khc) subunits that alternate cycles of microtubule binding, conformational change, and ATP hydrolysis. Mutations in the Drosophila Khc gene are known to cause distal paralysis and lethality preceded by the occurrence of dystrophic axon terminals, reduced axonal transport, organelle-filled axonal swellings, and impaired action potential propagation. Mutations in the equivalent human gen ...[more]