A low-fat dietary pattern and risk of metabolic syndrome in postmenopausal women: the Women's Health Initiative.

ABSTRACT:

Objective

Nutrition plays an important role in metabolic syndrome etiology. We examined whether the Women's Health Initiative (WHI) Dietary Modification Trial influenced metabolic syndrome risk.

Materials/methods

48,835 postmenopausal women aged 50-79 years were randomized to a low-fat (20% energy from fat) diet (intervention) or usual diet (comparison) for a mean of 8.1 years. Blood pressure, waist circumference and fasting blood measures of glucose, HDL-cholesterol and triglycerides were measured on a subsample (n=2816) at baseline and years 1, 3 and 6 post-randomization. Logistic regression estimated associations of the intervention with metabolic syndrome risk and use of cholesterol-lowering and hypertension medications. Multivariate linear regression tested associations

SUBMITTER: Neuhouser ML 

PROVIDER: S-EPMC3430820 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature