Ontology highlight
ABSTRACT:
SUBMITTER: Bell JT
PROVIDER: S-EPMC3430851 | biostudies-literature | 2011 Jan
REPOSITORIES: biostudies-literature
Bell Jordana T JT Timpson Nicholas J NJ Rayner N William NW Zeggini Eleftheria E Frayling Timothy M TM Hattersley Andrew T AT Morris Andrew P AP McCarthy Mark I MI
Annals of human genetics 20101206 1
In the presence of epistasis multilocus association tests of human complex traits can provide powerful methods to detect susceptibility variants. We undertook multilocus analyses in 1924 type 2 diabetes cases and 2938 controls from the Wellcome Trust Case Control Consortium (WTCCC). We performed a two-dimensional genome-wide association (GWA) scan using joint two-locus tests of association including main and epistatic effects in 70,236 markers tagging common variants. We found two-locus associat ...[more]