A new Oxyma derivative for nonracemizable amide-forming reactions in water.
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ABSTRACT:
SUBMITTER: Wang Q
PROVIDER: S-EPMC3431018 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
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A new Oxyma derivative for nonracemizable amide-forming reactions in water.
Wang Qinghui Q Wang Yong Y Kurosu Michio M
Organic letters 20120614 13
An Oxyma derivative, (2,2-dimethyl-1,3-dioxolan-4-yl)methyl 2-cyano-2-(hydroxyimino)acetate (2), displayed remarkable physicochemical properties as a peptide-coupling additive for peptide-forming reactions in water. Short peptides to oligopeptides could be synthesized by using 2, EDCI, and NaHCO(3) in water without measurable racemization. Significantly, a simple basic and acidic aqueous workup procedure can remove all reagents utilized in the reactions to afford only coupling products in consis ...[more]
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