Ontology highlight
ABSTRACT:
SUBMITTER: Solmaz SR
PROVIDER: S-EPMC3431207 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
Solmaz Sozanne R SR Chauhan Radha R Blobel Günter G Melčák Ivo I
Cell 20111001 3
The nuclear pore complex encloses a central channel for nucleocytoplasmic transport, which is thought to consist of three nucleoporins, Nup54, Nup58, and Nup62. However, the structure and composition of the channel are elusive. We determined the crystal structures of the interacting domains between these nucleoporins and pieced together the molecular architecture of the mammalian transport channel. Located in the channel midplane is a flexible Nup54⋅Nup58 ring that can undergo large rearrangemen ...[more]