Ontology highlight
ABSTRACT:
SUBMITTER: Stuwe T
PROVIDER: S-EPMC5180592 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Stuwe Tobias T Correia Ana R AR Lin Daniel H DH Paduch Marcin M Lu Vincent T VT Kossiakoff Anthony A AA Hoelz André A
Science (New York, N.Y.) 20150212 6226
The nuclear pore complex (NPC) constitutes the sole gateway for bidirectional nucleocytoplasmic transport. Despite half a century of structural characterization, the architecture of the NPC remains unknown. Here we present the crystal structure of a reconstituted ~400-kilodalton coat nucleoporin complex (CNC) from Saccharomyces cerevisiae at a 7.4 angstrom resolution. The crystal structure revealed a curved Y-shaped architecture and the molecular details of the coat nucleoporin interactions form ...[more]