Ontology highlight
ABSTRACT:
SUBMITTER: Calderon-Gomez E
PROVIDER: S-EPMC3431508 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Calderón-Gómez Elisabeth E Lampropoulou Vicky V Shen Ping P Neves Patricia P Roch Toralf T Stervbo Ulrik U Rutz Sascha S Kühl Anja A AA Heppner Frank L FL Loddenkemper Christoph C Anderton Stephen M SM Kanellopoulos Jean M JM Charneau Pierre P Fillatreau Simon S
European journal of immunology 20110525 6
Activated B cells can regulate immunity and have been envisaged as a potential cell-based therapy for treating autoimmune diseases. However, activated human B cells can also propagate immune responses, and the effects resulting from their infusion into patients cannot be predicted. This led us to consider resting B cells, which in contrast are poorly immunogenic, as an alternative cellular platform for the suppression of unwanted immunity. Here, we report that resting B cells can be directly eng ...[more]