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Activity-based near-infrared fluorescent probe for LMP7: a chemical proteomics tool for the immunoproteasome in living cells.

ABSTRACT: Probing the unknown: The immunoproteasome, an alternative form of the constitutive proteasome, has been implicated in a number of pathological states such as cancer and autoimmune diseases. In an effort to understand the role of the immunoproteasome in cells, the first immunoproteasome-specific near-infrared fluorescent probe has been developed.

SUBMITTER: Sharma LK

PROVIDER: S-EPMC3431601 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature

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Activity-based near-infrared fluorescent probe for LMP7: a chemical proteomics tool for the immunoproteasome in living cells.

Sharma Lalit Kumar LK Lee Na-Ra NR Jang Eun Ryoung ER Lei Beilei B Zhan Chang-Guo CG Lee Wooin W Kim Kyung-Bo KB

Chembiochem : a European journal of chemical biology 20120717 13

Probing the unknown: The immunoproteasome, an alternative form of the constitutive proteasome, has been implicated in a number of pathological states such as cancer and autoimmune diseases. In an effort to understand the role of the immunoproteasome in cells, the first immunoproteasome-specific near-infrared fluorescent probe has been developed. ...[more]

PMID: 22807337

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