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Near-Infrared Fluorescent Probe for Sensitive Detection of Pb(II) Ions in Living Cells.

ABSTRACT: A new near-infrared fluorescent probe (NIR-PbP) for sensitive detection of Pb(II) ions in solution and living cells has been rationally designed and synthesized. The NIR-PbP is inherently non-fluorescent and gains fluorescence in the presence Pb(II) ions. The ion detection is based on Pb(II)-induced unmasking the fluorophore through the opening of the spyrocycle, with more than 500-fold fluorescence for sub-micromolar Pb(II) concentration. The NIR-PbP has high sensitivity, good photo-stability, low detection limit, and reversible response to Pb(II) ions.

SUBMITTER: Bi J 

PROVIDER: S-EPMC6162053 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature

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Near-Infrared Fluorescent Probe for Sensitive Detection of Pb(II) Ions in Living Cells.

Bi Jianheng J   Fang Mingxi M   Wang Jianbo J   Xia Shuai S   Zhang Yibin Y   Zhang Jingtuo J   Vegesna Giri G   Zhang Shuwei S   Tanasova Marina M   Luo Fen-Tair FT   Liu Haiying H  

Inorganica chimica acta 20170620

A new near-infrared fluorescent probe (NIR-PbP) for sensitive detection of Pb(II) ions in solution and living cells has been rationally designed and synthesized. The NIR-PbP is inherently non-fluorescent and gains fluorescence in the presence Pb(II) ions. The ion detection is based on Pb(II)-induced unmasking the fluorophore through the opening of the spyrocycle, with more than 500-fold fluorescence for sub-micromolar Pb(II) concentration. The NIR-PbP has high sensitivity, good photo-stability,  ...[more]

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