Ontology highlight
ABSTRACT:
SUBMITTER: Joseph TL
PROVIDER: S-EPMC3432064 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Joseph Thomas L TL Lane David P DP Verma Chandra S CS
PloS one 20120831 8
Atomistic simulations of a set of stapled alpha helical peptides derived from the BH3 helix of MCL-1 (Stewart et al. (2010) Nat Chem Biol 6: 595-601) complexed to a fragment (residues 172-320) of MCL-1 revealed that the highest affinity is achieved when the staples engage the surface of MCL-1 as has also been demonstrated for p53-MDM2 (Joseph et al. (2010) Cell Cycle 9: 4560-4568; Baek et al. (2012) J Am Chem Soc 134: 103-106). Affinity is also modulated by the ability of the staples to pre-orga ...[more]